Article 14222

Title of the article

Morphofunctional markers of the efficiency stimulated by the pool proliferation of the nasal mucosa cells in patients with polyposis rinosinusitis 

Authors

Larisa S. Bakulina, Doctor of medical sciences, professor, professor of the sub-department of otorhinolaryngology, Voronezh State Medical University named after N.N. Burdenko (10 Studencheskaya street, Voronezh, Russia), E-mail: l.bakulina2014@mail.ru
Daniil Yu. Bugrimov, Candidate of medical sciences, associate professor of the sub-department of pathological anatomy, Voronezh State Medical University named after N.N. Burdenko (10 Studencheskaya street, Voronezh, Russia), E-mail: danikst@mail.ru
Olesya V. Lidokhova, Candidate of biological sciences, associate professor of the sub-department of pathological physiology, Voronezh State Medical University named after N.N. Burdenko (10 Studencheskaya street, Voronezh, Russia), E-mail: Lidohova@rambler.ru
Ol'ga V. Kashaeva, Candidate of medical sciences, associate professor, associate professor of the sub-department of pathological physiology, Moscow State Medical and Dental University named after A.I. Evdokimov (building 1, 20 Delegatskaya street, Moscow, Russia), E-mail: Kashaeva9@gmail.com 

Abstract

Background. The article highlights potential pathomorphological and pathophysiological mechanisms of effective treatment of polypous rhinosinusitis. Materials and methods. The study included patients diagnosed with bilateral polyposis rhinosinusitis, who were conducted immunohistochemical analysis of TLR9 expression using monoclonal antibodies in biopsy postoperative material (twice: prior to treatment and 20 days after treatment), and cytological examination of nasal reprint smears stained by Romanovsky-Giemsa method (immersion microscopy 7×90). Results. The study detected individual features of the proliferative activity of the epithelial pool of the nasal mucosa and pathological polyposis tissue in response to complex immunocorrective therapy. Conclusions. The results obtained allow including immunocorrective therapy in the complex treatment of polyposis rhinosinusitis to reduce possible relapses of the pathology. 

Key word

polyp, TLR9 expression, rhinosinusitis, pathological markers 

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For citation:

Bakulina L.S., Bugrimov D.Yu., Lidokhova O.V., Kashaeva O.V. Morphofunctional markers of the efficiency stimulated by the pool proliferation of the nasal mucosa cells in patients with polyposis rinosinusitis. Izvestiya vysshikh uchebnykh zavedeniy. Povolzhskiy region. Meditsinskie nauki = University proceedings. Volga region. Medical sciences. 2022;(2):135–142. (In Russ.). doi:10.21685/2072-3032-2022-2-14

 

Дата создания: 22.06.2022 08:38
Дата обновления: 22.06.2022 10:14